PHAGE RESISTANCE IN MULTIDRUG-RESISTANT KLEBSIELLA PNEUMONIAE ST258 EVOLVES VIA DIVERSE MUTATIONS THAT CULMINATE IN IMPAIRED ADSORPTION

Phage Resistance in Multidrug-Resistant Klebsiella pneumoniae ST258 Evolves via Diverse Mutations That Culminate in Impaired Adsorption

ABSTRACT The evolution of phage resistance poses an inevitable threat to the efficacy of phage therapy.The strategic selection of phage combinations that impose high genetic barriers to resistance and/or high compensatory fitness costs may mitigate this threat.However, for such a strategy to be effective, the evolution of phage resistance must be s

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The Sweet Potato NAC-Domain Transcription Factor IbNAC1 Is Dynamically Coordinated by the Activator IbbHLH3 and the Repressor IbbHLH4 to Reprogram the Defense Mechanism against Wounding.

IbNAC1 is known to activate the defense system by reprogramming a genetic network against herbivory in sweet potato.This regulatory activity elevates plant defense potential but relatively weakens plants by IbNAC1-mediated JA response.The mechanism controlling IbNAC1 expression to balance plant vitality and survival remains unclear.In this study, a

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Changes in the mRNA expression of glycolysis-related enzymes of Candida albicans during inhibition of intramitochondrial catabolism under anaerobic condition

Candida albicans can cause two major types of infections: superficial infection and systemic candidiasis.C.albicans infects diverse host niches, owing to a wide range of virulence factors and attributes, such as morphological transitions and phenotypic switching.C.albicans uses glycolysis, followed by alcoholic fermentation or mitochondrial respira

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pH-responsive targeted nanoparticles release ERK-inhibitor in the hypoxic zone and sensitize free gemcitabine in mutant K-Ras-addicted pancreatic cancer cells and mouse model.

Therapeutic options for managing Pancreatic ductal adenocarcinoma (PDAC), one of the deadliest types of aggressive malignancies, are limited and disappointing.Therefore, despite suboptimal clinical effects, gemcitabine (GEM) remains the first-line DVI-D Digital Video Cable chemotherapeutic drug in the clinic for PDAC treatment.The therapeutic limit

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